Very long-time period animal studies have not been performed to assess the carcinogenic potential of codeine or of promethazine, nor are there other animal or human information relating to carcinogenicity, mutagenicity, or impairment of fertility with these brokers.
The drug is excreted principally while in the urine, largely as inactive metabolites and little amounts of cost-free and conjugated morphine. Negligible quantities of codeine and its metabolites are found in the feces.
Cold, clammy skin dry mouth fainting no hypertension or pulse no muscle tone or movement pinpoint pupils (black part of the eye) halting of the guts unconsciousness Some Uncomfortable side effects may well take place that usually will not need medical focus.
Acquire this medication accurately as prescribed to decreased the potential risk of dependancy. Ask your health practitioner or pharmacist for more specifics.
Small children may be far more delicate to the Negative effects of the drug, especially slowed respiratory and uncontrolled movements (see also Warning part). Youngsters might also experience excitability rather than drowsiness.
Lactation At the least one Loss of life was described inside a nursing infant who was subjected to superior levels of morphine in breast milk as the mom was an ultra-fast metabolizer of codeine.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Remedy Recommend individuals to adequately get rid of unused Promethazine HCl and Codeine Phosphate Oral Remedy. Suggest clients to throw the drug within the household trash adhering to these actions. one) Get rid of them from their original containers and mix them having an unwanted material, which include applied espresso grounds or kitty litter (this will make the drug fewer appealing to children and pets, and unrecognizable to people who may perhaps intentionally go through the trash trying to find medicine).
Recommend sufferers to always use an precise milliliter measuring unit when measuring and administering Promethazine HCl and Codeine Phosphate Oral Solution. Tell individuals that a house teaspoon is just not an correct measuring product and this sort of use could lead on to overdosage and critical adverse reactions [see Overdosage (10)].
Read the Medication Guideline provided by your pharmacist before you start taking codeine/promethazine and every time you will get a refill. When you've got any questions, request your medical doctor or pharmacist.
It really is soluble in water and freely soluble in alcohol. It's a molecular pounds of 320.88, a molecular method of C17H20N2S•HCI, and the subsequent structural system:
This medication may well have sugar Promethazine codeine syrup and/or alcohol. Caution is suggested For those who have diabetic issues, Alcoholic beverages dependence, or liver disease. Check with your medical professional or pharmacist about making use of this item safely and securely.
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Concentration–Adverse Response Relationships You will find a relationship concerning growing codeine plasma focus and growing frequency of dose- connected opioid adverse reactions which include nausea, vomiting, CNS results, and respiratory depression.
Concomitant administration of promethazine products with other respiratory depressants has an Affiliation with respiratory despair, and from time to time Dying, in pediatric patients.